Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemia

摘要

NOTCH1 mutations are found in more than 50 % of patients with T-lineage acute lymphoblastic leukemia (TALL), and have been associated with a favorable outcome in pediatric T-ALL. FBXW7 mutations are found in a small subset of T-ALL, sometimes overlapping with the presence of NOTCH1 mutations. In this study, Baldus and colleagues investigated the prognostic impact of NOTCH1 and FBXW7 mutations in adult T-ALL. See related perspective article on page 1338.